Meiosis-Specific Loading of the Centromere-Specific Histone CENH3 in Arabidopsis thaliana
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Meiosis-Specific Loading of the Centromere-Specific Histone CENH3 in Arabidopsis thaliana
Centromere behavior is specialized in meiosis I, so that sister chromatids of homologous chromosomes are pulled toward the same side of the spindle (through kinetochore mono-orientation) and chromosome number is reduced. Factors required for mono-orientation have been identified in yeast. However, comparatively little is known about how meiotic centromere behavior is specialized in animals and ...
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Centromeres control chromosome inheritance in eukaryotes, yet their DNA structure and primary sequence are hypervariable. Most animals and plants have megabases of tandem repeats at their centromeres, unlike yeast with unique centromere sequences. Centromere function requires the centromere-specific histone CENH3 (CENP-A in human), which replaces histone H3 in centromeric nucleosomes. CENH3 evo...
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Centromeres are essential for correct chromosome segregation during cell division and are determined by the presence of centromere-specific histone 3 (CENH3). Most of the diploid plant species, in which the structure and copy number of CENH3 genes have been determined, have this gene as a singleton; however, some cereal species in the tribe Triticeae have been found to have CENH3 in two variant...
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Centromeres are specified by a centromere specific histone 3 (CENH3) protein, which exists in a complex environment, interacting with conserved proteins and rapidly evolving satellite DNA sequences. The interactions may become more challenging if multiple CENH3 versions are introduced into the zygote as this can affect post-zygotic mitosis and ultimately sexual reproduction. Here, we characteri...
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Vol 45 No 1 April 2014 AUSTRALIAN BIOCHEMIST Introduction In eukaryotes, chromosomal DNA needs to replicate, condense and segregate to daughter cells for accurate cell division to occur. Any errors in the chromosome segregation step can lead to common human diseases such as developmental disorders, cancer and infertility. The essential chromosome structure that is responsible for the faithful d...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2011
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1002121